Nitric Oxide Synthase Inhibition by NG-Nitro-l-Arginine Methyl Ester Inhibits Tumor-Induced Angiogenesis in Mammary Tumors
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منابع مشابه
The role of nitric oxide synthase in endotoxin-induced uveitis: effects of NG-nitro L-arginine.
PURPOSE To evaluate the role of nitric oxide synthase (NOS) in endotoxin-induced uveitis (EIU). METHODS EIU was caused in Lewis rats by injecting lipopolysaccharide (LPS) into the foot pad, and the effects of an NOS inhibitor, NG-nitro L-arginine (NA), was comparatively studied by the simultaneous administration of NA and LPS. Total NOS and inducible NOS (iNOS) activities were differentially ...
متن کاملTiming of administration of dexamethasone or the nitric oxide synthase inhibitor, nitro-L-arginine methyl ester,
1. The effects of the nitric oxide synthase (NOS) inhibitors, NG-nitro-L-arginine-methyl ester (L-NAME), nitroiminoethyl-L-ornithine and Smethylisothiourea on skeletal muscle survival following 2 h of tourniquet ischaemia and 24 h of reperfusion were compared with those of the antiinflammatory steroid, dexamethasone. 2. Administration of each of the NOS inhibitors or dexamethasone 30 min before...
متن کاملInduction of hypoxia in experimental murine tumors by the nitric oxide synthase inhibitor, NG-nitro-L-arginine.
The nitric oxide synthase inhibitor NG-nitro-L-arginine (NOARG) was examined for its ability to alter energy metabolism in three murine tumors using 31P magnetic resonance spectroscopy. NOARG (10 mg/kg, i.v.) increased the inorganic phosphate:total phosphate ratio (Pi:total) 2-3-fold in the KHT, RIF-1, and SCCVII/Ha intradermal back tumors from 30 min to 6 h after injection, but the 31P magneti...
متن کاملThe Nitric Oxide Synthase Inhibitor NG-Nitro-L-Arginine Methyl Ester Diminishes the Immunomodulatory Effects of Parental Arginine in Rats with Subacute Peritonitis
The combined treatment of parenteral arginine and the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) have been shown to improve liver function and systemic inflammation in subacute peritonitic rats. Here, we investigated the effects of single and combined parenteral arginine and L-NAME treatments on leukocyte and splenocyte immunity. Male Wistar rats were subjected to...
متن کاملInactivation of macrophage nitric oxide synthase activity by NG-methyl-L-arginine.
.N = O synthase catalyzes the oxidation of one of the two chemically equivalent guanido nitrogens of L-arginine to nitric oxide (.N = O). NG-Methyl-L-arginine has been previously characterized as a potent competitive inhibitor of both major types of .N = O synthases. Initial rate kinetics were performed with a spectrophotometric assay based on the oxidation of oxy- to methemoglobin by .N = O. N...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 1999
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)65240-6